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Article

Genetic influences on cognitive decline in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2012

Morley James F, Xie Sharon X, Hurtig Howard I, Stern Matthew B, Colcher Amy, Horn Stacy, Dahodwala Nabila, Duda John E, Weintraub Daniel, Chen-Plotkin Alice S, Van Deerlin Vivianna, Falcone Dana, Siderowf Andrew

Abstract excerpt

The role of genetic factors in cognitive decline associated with Parkinson's disease (PD) is unclear. We examined whether variations in apolipoprotein E (APOE), microtubule-associated protein tau (MAPT), or catechol-O-methytransferase (COMT) genotypes are associated with cognitive decline in PD. We performed a prospective cohort study of 212 patients with a clinical diagnosis of PD. The primary outcome was change...

Topics

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Apolipoproteins E
Catechol O-Methyltransferase
Cognition Disorders
Neuropsychological Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parkinson Disease

Psychiatric Status Rating Scales

Statistics, Nonparametric

Source

Open in PubMed Open full text

Identifiers

PMID: 22344634
DOI: 10.1002/mds.24946
PMCID: PMC3323737

Genes

APOE
COMT
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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