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Article

Alcohol consumption, DNA methylation and colorectal cancer risk: Results from pooled cohort studies and Mendelian randomization analysis.

International journal of cancer - 1 Jul 2022

Zhou Xuan, Wang Lijuan, Xiao Jiarui, Sun Jing, Yu Lili, Zhang Han, Meng Xiangrui, Yuan Shuai, Timofeeva Maria, Law Philip J, Houlston Richard S, Ding Kefeng, Dunlop Malcolm G, Theodoratou Evropi, Li Xue

Abstract excerpt

Alcohol consumption is thought to be one of the modifiable risk factors for colorectal cancer (CRC). However, the causality and mechanisms by which alcohol exerts its carcinogenic effect are unclear. We evaluated the association between alcohol consumption and CRC risk by analyzing data from 32 cohort studies and conducted two-sample Mendelian randomization (MR) analysis to examine for casual relationship. To...

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Identifiers

PMID: 35102554
DOI: 10.1002/ijc.33945
PMCID: PMC9487984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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