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The Associations of Tobacco, Alcohol, and Coffee Consumption with Upper and Lower Gastrointestinal Disease Risk: A Mendelian Randomization Study.

Gut and liver - 15 Sept 2025

Xue Fei, Xue Jiajing, Zhao Bingbing, Zhu Shuai

Abstract excerpt

Background/Aims: Gastrointestinal diseases present a significant global health challenge and greatly impact healthcare expenditures. Despite alcohol, tobacco, and coffee being universally recognized risk factors for various gastrointestinal disorders, the exact causal linkages have not been clarified because of the predominance of observational studies on this topic. Mendelian randomization (MR) was used to...

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Alcohol Drinking
Coffee
Gastrointestinal Diseases
Genome-Wide Association Study
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 40211908
DOI: 10.5009/gnl240440
PMCID: PMC12436049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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