Article
Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer.
PLoS genetics - 1 Oct 2016
Gong Jian, Hutter Carolyn M, Newcomb Polly A, Ulrich Cornelia M, Bien Stephanie A, Campbell Peter T, Baron John A, Berndt Sonja I, Bezieau Stephane, Brenner Hermann, Casey Graham, Chan Andrew T, Chang-Claude Jenny, Du Mengmeng, Duggan David, Figueiredo Jane C, Gallinger Steven, Giovannucci Edward L, Haile Robert W, Harrison Tabitha A, Hayes Richard B, Hoffmeister Michael, Hopper John L, Hudson Thomas J, Jeon Jihyoun, Jenkins Mark A, Kocarnik Jonathan, Küry Sébastien, Le Marchand Loic, Lin Yi, Lindor Noralane M, Nishihara Reiko, Ogino Shuji, Potter John D, Rudolph Anja, Schoen Robert E, Schrotz-King Petra, Seminara Daniela, Slattery Martha L, Thibodeau Stephen N, Thornquist Mark, Toth Reka, Wallace Robert, White Emily, Jiao Shuo, Lemire Mathieu, Hsu Li, Peters Ulrike
Abstract excerpt
Genome-wide association studies (GWAS) have identified many genetic susceptibility loci for colorectal cancer (CRC). However, variants in these loci explain only a small proportion of familial aggregation, and there are likely additional variants that are associated with CRC susceptibility. Genome-wide studies of gene-environment interactions may identify variants that are not detected in GWAS of marginal gene...
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