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mTORC1 and ferroptosis: Regulatory mechanisms and therapeutic potential

14 Jun 2021

Abstract excerpt

Ferroptosis, a form of regulated cell death triggered by lipid hydroperoxide accumulation, has an important role in a variety of diseases and pathological conditions, such as cancer. Targeting ferroptosis is emerging as a promising means of therapeutic intervention in cancer treatment. Polyunsaturated fatty acids, reactive oxygen species, and labile iron constitute the major underlying triggers for ferroptosis....

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PMID: 34121197
DOI: 10.1002/bies.202100093

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