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Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury

9 Jul 2021

Abstract excerpt

Prokineticin-2 (Prok2) is an important secreted protein likely involved in the pathogenesis of several acute and chronic neurological diseases through currently unidentified regulatory mechanisms. The initial mechanical injury of neurons by traumatic brain injury triggers multiple secondary responses including various cell death programs. One of these is ferroptosis, which is associated with dysregulation of iron...

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PMID: 34244497
DOI: 10.1038/s41467-021-24469-y

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