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Article

Mutation of Mycobacterium tuberculosis and Implications for Using Whole-Genome Sequencing for Investigating Recent Tuberculosis Transmission.

Frontiers in public health - 1 Jan 2021

Nelson Kristin N, Talarico Sarah, Poonja Shameer, McDaniel Clinton J, Cilnis Martin, Chang Alicia H, Raz Kala, Noboa Wendy S, Cowan Lauren, Shaw Tambi, Posey James, Silk Benjamin J

Abstract excerpt

Tuberculosis (TB) control programs use whole-genome sequencing (WGS) of Mycobacterium tuberculosis (Mtb) for detecting and investigating TB case clusters. Existence of few genomic differences between Mtb isolates might indicate TB cases are the result of recent transmission. However, the variable and sometimes long duration of latent infection, combined with uncertainty in the Mtb mutation rate during latency,...

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Source

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Identifiers

PMID: 35096744
DOI: 10.3389/fpubh.2021.790544
PMCID: PMC8793027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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