Article
Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities.
The European respiratory journal - 1 Oct 2018
Auld Sara C, Shah N Sarita, Mathema Barun, Brown Tyler S, Ismail Nazir, Omar Shaheed Vally, Brust James C M, Nelson Kristin N, Allana Salim, Campbell Angela, Mlisana Koleka, Moodley Pravi, Gandhi Neel R
Abstract excerpt
Despite evidence that transmission is driving an extensively drug-resistant TB (XDR-TB) epidemic, our understanding of where and between whom transmission occurs is limited. We sought to determine whether there was genomic evidence of transmission between individuals without an epidemiologic connection.We conducted a prospective study of XDR-TB patients in KwaZulu-Natal, South Africa, during the 2011-2014 period....
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