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Article

Whole genome sequencing versus traditional genotyping for investigation of a Mycobacterium tuberculosis outbreak: a longitudinal molecular epidemiological study.

PLoS medicine - 1 Jan 2013

Roetzer Andreas, Diel Roland, Kohl Thomas A, Rückert Christian, Nübel Ulrich, Blom Jochen, Wirth Thierry, Jaenicke Sebastian, Schuback Sieglinde, Rüsch-Gerdes Sabine, Supply Philip, Kalinowski Jörn, Niemann Stefan

Abstract excerpt

BACKGROUND: Understanding Mycobacterium tuberculosis (Mtb) transmission is essential to guide efficient tuberculosis control strategies. Traditional strain typing lacks sufficient discriminatory power to resolve large outbreaks. Here, we tested the potential of using next generation genome sequencing for identification of outbreak-related transmission chains. METHODS AND FINDINGS: During long-term (1997 to 2010)...

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Identifiers

PMID: 23424287
DOI: 10.1371/journal.pmed.1001387
PMCID: PMC3570532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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