Article
Large-scale whole genome sequencing of M. tuberculosis provides insights into transmission in a high prevalence area.
eLife - 3 Mar 2015
Guerra-Assunção J A, Crampin A C, Houben R M G J, Mzembe T, Mallard K, Coll F, Khan P, Banda L, Chiwaya A, Pereira R P A, McNerney R, Fine P E M, Parkhill J, Clark T G, Glynn J R
Abstract excerpt
To improve understanding of the factors influencing tuberculosis transmission and the role of pathogen variation, we sequenced all available specimens from patients diagnosed over 15 years in a whole district in Malawi. Mycobacterium tuberculosis lineages were assigned and transmission networks constructed, allowing ≤10 single nucleotide polymorphisms (SNPs) difference. We defined disease as due to recent...
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