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Article

Prioritization of Genes Relevant to Bone Fragility Through the Unbiased Integration of Aging Mouse Bone Transcriptomics and Human GWAS Analyses.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2022

Kaya Serra, Schurman Charles A, Dole Neha S, Evans Daniel S, Alliston Tamara

Abstract excerpt

Identifying new genetic determinants of bone mineral density (BMD) and fracture promises to yield improved diagnostics and therapies for bone fragility. However, prioritizing candidate genes from genome-wide screens can be challenging. To overcome this challenge, we prioritized mouse genes that are differentially expressed in aging mouse bone based on whether their human homolog is associated with human BMD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fractures, Bone

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 35094432
DOI: 10.1002/jbmr.4516
PMCID: PMC9018503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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