Article
Rapid phenotyping of knockout mice to identify genetic determinants of bone strength.
The Journal of endocrinology - 1 Oct 2016
Freudenthal Bernard, Logan John, Croucher Peter I, Williams Graham R, Bassett J H Duncan
Abstract excerpt
The genetic determinants of osteoporosis remain poorly understood, and there is a large unmet need for new treatments in our ageing society. Thus, new approaches for gene discovery in skeletal disease are required to complement the current genome-wide association studies in human populations. The International Knockout Mouse Consortium (IKMC) and the International Mouse Phenotyping Consortium (IMPC) provide such...
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