Article
Joint mouse-human phenome-wide association to test gene function and disease risk.
Nature communications - 2 Feb 2016
Wang Xusheng, Pandey Ashutosh K, Mulligan Megan K, Williams Evan G, Mozhui Khyobeni, Li Zhengsheng, Jovaisaite Virginija, Quarles L Darryl, Xiao Zhousheng, Huang Jinsong, Capra John A, Chen Zugen, Taylor William L, Bastarache Lisa, Niu Xinnan, Pollard Katherine S, Ciobanu Daniel C, Reznik Alexander O, Tishkov Artem V, Zhulin Igor B, Peng Junmin, Nelson Stanley F, Denny Joshua C, Auwerx Johan, Lu Lu, Williams Robert W
Abstract excerpt
Phenome-wide association is a novel reverse genetic strategy to analyze genome-to-phenome relations in human clinical cohorts. Here we test this approach using a large murine population segregating for ∼5 million sequence variants, and we compare our results to those extracted from a matched analysis of gene variants in a large human cohort. For the mouse cohort, we amassed a deep and broad open-access phenome...
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