[Clonal hematopoiesis and myeloid neoplasms: from molecular basis to clinical implications].

Abstract excerpt

Clonal hematopoiesis (CH) refers to the age-associated expansion of hematopoietic stem cell clones carrying somatic mutations that are commonly observed in myeloid malignancies. With the widespread use of next-generation sequencing, such mutations are now frequently detected even in individuals without overt hematologic abnormalities. CH in the absence of cytopenia or hematologic malignancy is defined as clonal...

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• Cell Transformation, Neoplastic
• Clonal Hematopoiesis
• Dioxygenases
• DNA-Binding Proteins
• DNA Methyltransferase 3A