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Clonal hematopoiesis of indeterminate potential and cardiovascular disease: Pathogenesis, clinical presentation, and future directions.

Progress in cardiovascular diseases - 1 Jan 2024

Gajagowni Saivaroon, Hopkins Steven, Qadeer Yusuf, Virani Salim S, Verdonschot Job A J, Coombs Catherine C, Amos Christopher I, Nead Kevin T, Jaiswal Siddhartha, Krittanawong Chayakrit

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is a well-studied phenomenon in hematologic malignancies. With advancements in gene sampling and analysis and the use of large cohort studies, CHIP has recently been linked to cardiovascular disease (CVD). The relationship between CHIP and CVD appears to be bidirectional, with traditional risk factors for cardiovascular disease increasing the mutation burden...

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PMID: 39278303
DOI: 10.1016/j.pcad.2024.09.001

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