Article
Towards unveiling the nature of short SERPINA1 transcripts: Avoiding the main ORF control to translate alpha1-antitrypsin C-terminal peptides.
International journal of biological macromolecules - 1 Apr 2022
Maslakova A A, Didych D A, Golyshev S A, Katrukha I A, Viushkov V S, Zamalutdinov A V, Potashnikova D M, Rubtsov M A, Smirnova O V, Orlovsky I V
Abstract excerpt
Alternative ORFs in-frame with the known genes are challenging to reveal. Yet they may contribute significantly to proteome diversity. Here we focused on the individual expression of the SERPINA1 gene exon 5 leading to direct translation of alpha1-antitrypsin (AAT) C-terminal peptides. The discovery of alternative ways for their production may expand the current understanding of the serpin gene's functioning. We...
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