Article

5′ UTR length regulates alternative N-terminal protein isoform production in health and disease

2026-01-22

Abstract excerpt

The 5′ untranslated region (5′ UTR) of an mRNA is classically viewed as a regulatory region that controls the amount of protein production, but not the resulting protein sequence. Here, we demonstrate that 5′ UTR length plays a direct role in alternative N-terminal protein isoform production by controlling start codon selection. We find that very short 5′ UTRs enhance leaky ribosome scanning, thereby promoting the...

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Literature Corpus work: ad53177e-c77f-567f-a0d3-0d723f9a9e98
DOI: 10.64898/2026.01.20.700518

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