Article
LINEAGE: Label-free identification of endogenous informative single-cell mitochondrial RNA mutation for lineage analysis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 2022
Lin Li, Zhang Yufeng, Qian Weizhou, Liu Yao, Zhang Yingkun, Lin Fanghe, Liu Cenxi, Lu Guangxing, Sun Di, Guo Xiaoxu, Song YanLing, Song Jia, Yang Chaoyong, Li Jin
Abstract excerpt
Single-cell RNA-sequencing (scRNA-seq) has become a powerful tool for biomedical research by providing a variety of valuable information with the advancement of computational tools. Lineage analysis based on scRNA-seq provides key insights into the fate of individual cells in various systems. However, such analysis is limited by several technical challenges. On top of the considerable computational expertise and...
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