Article
The mitochondrial brain: From mitochondrial genome to neurodegeneration.
Biochimica et biophysica acta - 1 Jan 2010
Turnbull Helen E, Lax Nichola Z, Diodato Daria, Ansorge Olaf, Turnbull Doug M
Abstract excerpt
Mitochondrial DNA mutations are an important cause of neurological disease. The clinical presentation is very varied in terms of age of onset and different neurological signs and symptoms. The clinical course varies considerably but in many patients there is a progressive decline, and in some evidence of marked neurodegeneration. Our understanding of the mechanisms involved is limited due in part to limited...
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