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Article

Mitochondrial DNA Variation in the Aging Human Cerebral Cortex and Cerebellum.

Aging cell - 1 Jan 2026

Omidsalar Audrey A, Tyrpak David R, MacKay J Andrew, Yen Kelvin, Cohen Pinchas, Serrano Geidy, Beach Thomas G, Nalls Michael A, Hernandez Dena G, Cookson Mark R, Singleton Andrew B, Gibbs J Raphael, Hjelm Brooke E

Abstract excerpt

Somatic differences in mitochondrial DNA (mtDNA) have been observed with aging and between brain regions for mutations, structural variation, and abundance, which are represented by single nucleotide variants (SNVs), large deletions, and copy number, respectively. We used bioinformatic methods to interrogate mtDNA changes and their relation to cortical and cerebellar aging using whole genome sequencing data from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41432549
DOI: 10.1111/acel.70340
PMCID: PMC12724393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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