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Article

The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner.

PLoS biology - 1 Jan 2022

Tóth Krisztina, Lénárt Nikolett, Berki Péter, Fekete Rebeka, Szabadits Eszter, Pósfai Balázs, Cserép Csaba, Alatshan Ahmad, Benkő Szilvia, Kiss Dániel, Hübner Christian A, Gulyás Attila, Kaila Kai, Környei Zsuzsanna, Dénes Ádám

Abstract excerpt

The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, the main inflammatory cells of the brain, has remained unclear to date. Therefore, we generated a novel transgenic mouse line in which microglial NKCC1 was deleted. We show that microglial NKCC1 shapes both baseline and reactive microglia morphology, process recruitment to the site of...

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Identifiers

PMID: 35085235
DOI: 10.1371/journal.pbio.3001526
PMCID: PMC8856735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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