Article

Chronic kidney disease leads to microglial potassium efflux and inflammasome activation in the brain

2024-06-06

Abstract excerpt

<title>Abstract</title> <p>Cognitive impairment is common in peripheral diseases such as chronic kidney disease (CKD). Kidney transplantation reverses cognitive impairment, indicating that cognitive impairment driven by CKD is therapeutically amendable. Yet, we lack mechanistic insights allowing targeted therapies. Using a combination of mouse models (including mice with neuron-specific IL-1R1 deficiency), single...

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Literature Corpus work: f48220ef-d44b-560f-b573-4391595368ae
DOI: 10.21203/rs.3.rs-2511118/v2

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