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Article

Influence of blood-brain barrier and intestinal barrier on microglial phenotypes: a perspective of clinical and prognostic implications.

Frontiers in immunology - 1 Jan 2026

Lima Maiara N, Santos Lucas F, Simões Lemos Felipe, Alves Reis Patricia, Maron-Gutierrez Tatiana, Castro-Faria-Neto Hugo C

Abstract excerpt

Microglia are highly specialized immune cells of the central nervous system (CNS). These cells exhibit remarkable plasticity, enabling them to adopt distinct phenotypes and functional profiles in response to changes in their microenvironment. Biological barriers, such as the blood-brain barrier (BBB) and the intestinal barrier, play a crucial role in maintaining the organism's homeostasis, protecting organs and...

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Identifiers

PMID: 42238577
DOI: 10.3389/fimmu.2026.1663796
PMCID: PMC13226031

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