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Article

Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population.

Clinical and translational science - 1 Sept 2022

Bråten Line Skute, Ingelman-Sundberg Magnus, Jukic Marin M, Molden Espen, Kringen Marianne Kristiansen

Abstract excerpt

Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the current study we have examined the role of a newly discovered ultrarapid CYP2C:TG haplotype and CYP2B6 variants in order to identify the possible missing heritability for such...

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Share to Cytochrome P-450 CYP2B6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35668575
DOI: 10.1111/cts.13347
PMCID: PMC9468554

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