Article
Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.
Molecular biology of the cell - 1 Mar 2009
Potapova Tamara A, Daum John R, Byrd Kendra S, Gorbsky Gary J
Abstract excerpt
Inactivation of cyclin-dependent kinase (Cdk) 1 promotes exit from mitosis and establishes G1. Proteolysis of cyclin B is the major known mechanism that turns off Cdk1 during mitotic exit. Here, we show that mitotic exit also activates pathways that catalyze inhibitory phosphorylation of Cdk1, a mechanism previously known to repress Cdk1 only during S and G2 phases of the cell cycle. We present evidence that...
Topics
- Animals
- CDC2 Protein Kinase
- Cell Cycle
- Enzyme Activation
- Humans
- Mutation
- Phosphorylation
- Protein Kinase Inhibitors
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Signal Transduction
- Time Factors
- Xenopus Proteins
- Xenopus laevis