Article
CRISPR-Cas9 systems: versatile cancer modelling platforms and promising therapeutic strategies.
International journal of cancer - 15 Mar 2016
Wen Wan-Shun, Yuan Zhi-Min, Ma Shi-Jie, Xu Jiang, Yuan Dong-Tang
Abstract excerpt
The RNA-guided nuclease CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR associated nuclease 9) and its variants such as nickase Cas9, dead Cas9, guide RNA scaffolds and RNA-targeting Cas9 are convenient and versatile platforms for site-specific genome editing and epigenome modulation. They are easy-to-use, simple-to-design and capable of targeting multiple loci simultaneously. Given...
Topics
- Animals
- CRISPR-Cas Systems
- Epigenesis, Genetic
- Humans
- Mutation
- Neoplasms
- RNA Editing
- RNA, Guide, CRISPR-Cas Systems