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Article

The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease.

Biochimica et biophysica acta. Proteins and proteomics - 1 Sept 2017

Wenta Tomasz, Glaza Przemysław, Jarząb Mirosław, Zarzecka Urszula, Żurawa-Janicka Dorota, Lesner Adam, Skórko-Glonek Joanna, Lipińska Barbara

Abstract excerpt

Human HtrA3 protease is a proapoptotic protein, involved in embryo implantation and oncogenesis. In stress conditions the protease is activated by removal of its N-terminal domain. The activated form, ΔN-HtrA3L is a homotrimer composed of the protease (PD) and PDZ domains. The LB structural loop of the PD is longer by six amino acid residues than its counterparts of other human HtrA proteins and interacts with...

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Identifiers

PMID: 28642151
DOI: 10.1016/j.bbapap.2017.06.013

Genes

XIAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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