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Machine learning optimized polygenic scores for blood cell traits identify sex-specific trajectories and genetic correlations with disease

1 Jan 2022

Abstract excerpt

Genetic association studies for blood cell traits, which are key indicators of health and immune function, have identified several hundred associations and defined a complex polygenic architecture. Polygenic scores (PGSs) for blood cell traits have potential clinical utility in disease risk prediction and prevention, but designing PGS remains challenging and the optimal methods are unclear. To address this, we...

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PMID: 35072137
DOI: 10.1016/j.xgen.2021.100086

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