Article

Variational Autoencoder-based Model Improves Polygenic Prediction in Blood Cell Traits

2025-01-18

Abstract excerpt

Genetic prediction of complex traits, enabled by large-scale genomic studies, has created new measures to understand individual genetic predisposition. Polygenic Risk Scores (PRS) offer a way to aggregate information across the genome, enabling personalized risk prediction for complex traits and diseases. However, conventional PRS calculation methods that rely on linear models are limited in their ability to captu...

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Literature Corpus work: d233773f-6ee8-5488-b25c-614b04b93d77
DOI: 10.1101/2025.01.13.632820

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