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Article

Variational autoencoder-based model improves polygenic prediction in blood cell traits.

HGG advances - 9 Oct 2025

Li Xiaoqi, Kharitonova Elena, Pang Minxing, Wen Jia, Zhou Laura Y, Raffield Laura, Zhou Haibo, Yao Huaxiu, Chen Can, Li Yun, Sun Quan

Abstract excerpt

Genetic prediction of complex traits, enabled by large-scale genomic studies, has created new measures to understand individual genetic predisposition. Polygenic risk scores (PRSs) offer a way to aggregate information across the genome, enabling personalized risk prediction for complex traits and diseases. However, conventional PRS calculation methods that rely on linear models are limited in their ability to...

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Identifiers

PMID: 40783786
DOI: 10.1016/j.xhgg.2025.100490
PMCID: PMC12398231

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