Article
The Polygenic and Monogenic Basis of Blood Traits and Diseases.
Cell - 3 Sept 2020
Vuckovic Dragana, Bao Erik L, Akbari Parsa, Lareau Caleb A, Mousas Abdou, Jiang Tao, Chen Ming-Huei, Raffield Laura M, Tardaguila Manuel, Huffman Jennifer E, Ritchie Scott C, Megy Karyn, Ponstingl Hannes, Penkett Christopher J, Albers Patrick K, Wigdor Emilie M, Sakaue Saori, Moscati Arden, Manansala Regina, Lo Ken Sin, Qian Huijun, Akiyama Masato, Bartz Traci M, Ben-Shlomo Yoav, Beswick Andrew, Bork-Jensen Jette, Bottinger Erwin P, Brody Jennifer A, van Rooij Frank J A, Chitrala Kumaraswamy N, Wilson Peter W F, Choquet Hélène, Danesh John, Di Angelantonio Emanuele, Dimou Niki, Ding Jingzhong, Elliott Paul, Esko Tõnu, Evans Michele K, Felix Stephan B, Floyd James S, Broer Linda, Grarup Niels, Guo Michael H, Guo Qi, Greinacher Andreas, Haessler Jeff, Hansen Torben, Howson Joanna M M, Huang Wei, Jorgenson Eric, Kacprowski Tim, Kähönen Mika, Kamatani Yoichiro, Kanai Masahiro, Karthikeyan Savita, Koskeridis Fotios, Lange Leslie A, Lehtimäki Terho, Linneberg Allan, Liu Yongmei, Lyytikäinen Leo-Pekka, Manichaikul Ani, Matsuda Koichi, Mohlke Karen L, Mononen Nina, Murakami Yoshinori, Nadkarni Girish N, Nikus Kjell, Pankratz Nathan, Pedersen Oluf, Preuss Michael, Psaty Bruce M, Raitakari Olli T, Rich Stephen S, Rodriguez Benjamin A T, Rosen Jonathan D, Rotter Jerome I, Schubert Petra, Spracklen Cassandra N, Surendran Praveen, Tang Hua, Tardif Jean-Claude, Ghanbari Mohsen, Völker Uwe, Völzke Henry, Watkins Nicholas A, Weiss Stefan, Cai Na, Kundu Kousik, Watt Stephen B, Walter Klaudia, Zonderman Alan B, Cho Kelly, Li Yun, Loos Ruth J F, Knight Julian C, Georges Michel, Stegle Oliver, Evangelou Evangelos, Okada Yukinori, Roberts David J, Inouye Michael, Johnson Andrew D, Auer Paul L, Astle William J, Reiner Alexander P, Butterworth Adam S, Ouwehand Willem H, Lettre Guillaume, Sankaran Vijay G, Soranzo Nicole
Abstract excerpt
Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including data for 563,085 European ancestry participants, and discover 5,106 new genetic variants independently associated...
