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Article

Temperature Trajectory Sub-phenotypes and the Immuno-Inflammatory Response in Pediatric Sepsis.

Shock (Augusta, Ga.) - 1 May 2022

Yehya Nadir, Fitzgerald Julie C, Hayes Katie, Zhang Donglan, Bush Jenny, Koterba Natalka, Chen Fang, Tuluc Florin, Teachey David T, Balamuth Fran, Lacey Simon F, Melenhorst Jan Joseph, Weiss Scott L

Abstract excerpt

OBJECTIVE: Heterogeneity has hampered sepsis trials, and sub-phenotyping may assist with enrichment strategies. However, biomarker-based strategies are difficult to operationalize. Four sub-phenotypes defined by distinct temperature trajectories in the first 72 h have been reported in adult sepsis. Given the distinct epidemiology of pediatric sepsis, the existence and relevance of temperature trajectory-defined...

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Identifiers

PMID: 35066512
DOI: 10.1097/SHK.0000000000001906
PMCID: PMC9117394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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