Distinct immune profiles and clinical outcomes in sepsis subphenotypes based on temperature trajectories.

doi:10.1007/s00134-024-07669-0

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Distinct immune profiles and clinical outcomes in sepsis subphenotypes based on temperature trajectories.

Intensive care medicine - 1 Dec 2024

Bhavani Sivasubramanium V, Spicer Alexandra, Sinha Pratik, Malik Albahi, Lopez-Espina Carlos, Schmalz Lee, Watson Gregory L, Bhargava Akhil, Khan Shah, Urdiales Dennys, Updike Lincoln, Dagan Alon, Davila Hugo, Demarco Carmen, Evans Neil, Gosai Falgun, Iyer Karthik, Kurtzman Niko, Palagiri Ashok V, Sims Matthew, Smith Scott, Syed Anwaruddin, Sarma Deesha, Reddy Bobby, Verhoef Philip A, Churpek Matthew M

Abstract excerpt

PURPOSE: Sepsis is a heterogeneous syndrome. Identification of sepsis subphenotypes with distinct immune profiles could lead to targeted therapies. This study investigates the immune profiles of patients with sepsis following distinct body temperature patterns (i.e., temperature trajectory subphenotypes). METHODS: Hospitalized patients from four hospitals between 2018 and 2022 with suspicion of infection were...

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PMID: 39382693
DOI: 10.1007/s00134-024-07669-0
PMCID: PMC12674214

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