Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock.

doi:10.1097/PCC.0000000000003499

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Article

Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies - 1 Jun 2024

Atreya Mihir R, Bennett Tellen D, Geva Alon, Faustino E Vincent S, Rogerson Colin M, Lutfi Riad, Cvijanovich Natalie Z, Bigham Michael T, Nowak Jeffrey, Schwarz Adam J, Baines Torrey, Haileselassie Bereketeab, Thomas Neal J, Luo Yuan, Sanchez-Pinto L Nelson

Abstract excerpt

OBJECTIVES: Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. We sought to the determine reproducibility of the data-driven "persistent hypoxemia, encephalopathy, and shock" (PHES) phenotype and determine its association with inflammatory and endothelial biomarkers, as well as biomarker-based pediatric risk strata. DESIGN:...

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PMID: 38465952
DOI: 10.1097/PCC.0000000000003499
PMCID: PMC11153020

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