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Article

Manganese-induced hyperactivity and dopaminergic dysfunction depend on age, sex and YAC128 genotype.

Pharmacology, biochemistry, and behavior - 1 Feb 2022

Wilcox Jordyn M, Consoli David C, Paffenroth Krista C, Spitznagel Brittany D, Calipari Erin S, Bowman Aaron B, Harrison Fiona E

Abstract excerpt

Manganese (Mn) is an essential micronutrient but is neurotoxic in excess. Environmental and genetic factors influence vulnerability to Mn toxicity, including sex, age, and the autosomal dominant mutation that causes Huntington disease (HD). To better understand the differential effects of Mn in wild-type (WT) versus YAC128 mice, we examined impacts of Mn exposure across different ages and sexes on...

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Identifiers

PMID: 35063467
DOI: 10.1016/j.pbb.2022.173337
PMCID: PMC8833139

Genes

TH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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