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Huntington's disease genotype suppresses global manganese-responsive processes in pre-manifest and manifest YAC128 mice.

Metallomics : integrated biometal science - 22 Jul 2020

Pfalzer Anna C, Wilcox Jordyn M, Codreanu Simona G, Totten Melissa, Bichell Terry J V, Halbesma Timothy, Umashanker Preethi, Yang Kevin L, Parmalee Nancy L, Sherrod Stacy D, Erikson Keith M, Harrison Fiona E, McLean John A, Aschner Michael, Bowman Aaron B

Abstract excerpt

Manganese (Mn) is an essential micronutrient required for the proper function of several enzymes. Accumulating evidence demonstrates a selective decrease of bioavailable Mn in vulnerable cell types of Huntington's Disease (HD), an inherited progressive neurodegenerative disorder with no cure. Amelioration of underlying pathophysiology, such as alterations in Mn-dependent biology, may be therapeutic. We therefore...

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PMID: 32421118
DOI: 10.1039/d0mt00081g
PMCID: PMC7773276

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