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Article

Ascorbate deficiency decreases dopamine release in gulo-/- and APP/PSEN1 mice.

Journal of neurochemistry - 1 May 2021

Consoli David C, Brady Lillian J, Bowman Aaron B, Calipari Erin S, Harrison Fiona E

Abstract excerpt

Dopamine (DA) has important roles in learning, memory, and motivational processes and is highly susceptible to oxidation. In addition to dementia, Alzheimer's disease (AD) patients frequently exhibit decreased motivation, anhedonia, and sleep disorders, suggesting deficits in dopaminergic neurotransmission. Vitamin C (ascorbate, ASC) is a critical antioxidant in the brain and is often depleted in AD patients as a...

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Source

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Identifiers

PMID: 32797675
DOI: 10.1111/jnc.15151
PMCID: PMC7882008

Genes

APP
PSEN1
TH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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