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Article

Linking protein structural and functional change to mutation using amino acid networks.

PloS one - 1 Jan 2022

Sotomayor-Vivas Cristina, Hernández-Lemus Enrique, Dorantes-Gilardi Rodrigo

Abstract excerpt

The function of a protein is strongly dependent on its structure. During evolution, proteins acquire new functions through mutations in the amino-acid sequence. Given the advance in deep mutational scanning, recent findings have found functional change to be position dependent, notwithstanding the chemical properties of mutant and mutated amino acids. This could indicate that structural properties of a given...

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Identifiers

PMID: 35061689
DOI: 10.1371/journal.pone.0261829
PMCID: PMC8782487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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