Article
Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions.
Nucleic acids research - 1 Jan 2015
Betts Matthew J, Lu Qianhao, Jiang YingYing, Drusko Armin, Wichmann Oliver, Utz Mathias, Valtierra-Gutiérrez Ilse A, Schlesner Matthias, Jaeger Natalie, Jones David T, Pfister Stefan, Lichter Peter, Eils Roland, Siebert Reiner, Bork Peer, Apic Gordana, Gavin Anne-Claude, Russell Robert B
Abstract excerpt
Systematic interrogation of mutation or protein modification data is important to identify sites with functional consequences and to deduce global consequences from large data sets. Mechismo (mechismo.russellab.org) enables simultaneous consideration of thousands of 3D structures and biomolecular interactions to predict rapidly mechanistic consequences for mutations and modifications. As useful functional...
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