Article

Protein Stability Changes upon Point Mutations Identified with a Gaussian Network Model Simulating Protein Unfolding Behavior

2022-02-19

Abstract excerpt

Understanding the effects of missense mutations on protein stability is a widely acknowledged significant biological problem. Genomic missense mutations may alter one or more amino acids leading to increased or decreased stability of the encoded proteins. In this study, we propose a novel approach - Protein Stability Prediction with a Gaussian Network Model (PSP-GNM) to study the effect of single amino acid substi...

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Literature Corpus work: 148ba594-b76b-51b7-9e9a-2f890f18efbf
DOI: 10.1101/2022.02.17.480818

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