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Article

Correlating protein function and stability through the analysis of single amino acid substitutions.

BMC bioinformatics - 27 Aug 2009

Bromberg Yana, Rost Burkhard

Abstract excerpt

BACKGROUND: Mutations resulting in the disruption of protein function are the underlying causes of many genetic diseases. Some mutations affect the number of expressed proteins while others alter the activity on a per-molecule basis. Single amino acid substitutions as caused by non-synonymous Single Nucleotide Polymorphisms (nsSNPs) often disrupt function by altering protein structure and/or stability, but can...

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Identifiers

PMID: 19758472
DOI: 10.1186/1471-2105-10-S8-S8
PMCID: PMC2745590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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