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Article

Predicting the Effect of Single and Multiple Mutations on Protein Structural Stability.

Molecules (Basel, Switzerland) - 27 Jan 2018

Dehghanpoor Ramin, Ricks Evan, Hursh Katie, Gunderson Sarah, Farhoodi Roshanak, Haspel Nurit, Hutchinson Brian, Jagodzinski Filip

Abstract excerpt

Predicting how a point mutation alters a protein's stability can guide pharmaceutical drug design initiatives which aim to counter the effects of serious diseases. Conducting mutagenesis studies in physical proteins can give insights about the effects of amino acid substitutions, but such wet-lab work is prohibitive due to the time as well as financial resources needed to assess the effect of even a single amino...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29382060
DOI: 10.3390/molecules23020251
PMCID: PMC6017198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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