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Article

Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content.

BMC cancer - 20 Jan 2022

Ganesamoorthy Devika, Robertson Alan James, Chen Wenhan, Hall Michael B, Cao Minh Duc, Ferguson Kaltin, Lakhani Sunil R, Nones Katia, Simpson Peter T, Coin Lachlan J M

Abstract excerpt

BACKGROUND: Circulating cell-free DNA (cfDNA) in the plasma of cancer patients contains cell-free tumour DNA (ctDNA) derived from tumour cells and it has been widely recognized as a non-invasive source of tumour DNA for diagnosis and prognosis of cancer. Molecular profiling of ctDNA is often performed using targeted sequencing or low-coverage whole genome sequencing (WGS) to identify tumour specific somatic...

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Identifiers

PMID: 35057759
DOI: 10.1186/s12885-021-09160-1
PMCID: PMC8772083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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