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Article

Detection of genomic alterations in breast cancer with circulating tumour DNA sequencing.

Scientific reports - 8 Oct 2020

Kleftogiannis Dimitrios, Ho Danliang, Liew Jun Xian, Poon Polly S Y, Gan Anna, Ng Raymond Chee-Hui, Tan Benita Kiat-Tee, Tay Kiang Hiong, Lim Swee H, Tan Gek San, Shih Chih Chuan, Lim Tony Kiat-Hon, Lee Ann Siew-Gek, Tan Iain Beehuat, Yap Yoon-Sim, Ng Sarah B

Abstract excerpt

Analysis of circulating cell-free DNA (cfDNA) has opened new opportunities for characterizing tumour mutational landscapes with many applications in genomic-driven oncology. We developed a customized targeted cfDNA sequencing approach for breast cancer (BC) using unique molecular identifiers (UMIs) for error correction. Our assay, spanning a 284.5 kb target region, is combined with a novel freely-licensed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33033274
DOI: 10.1038/s41598-020-72818-6
PMCID: PMC7544894

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