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H3.3G34W immunohistochemistry negative giant cell tumour of bone. Extended analysis of 35 such cases from a single institution in India.

Virchows Archiv : an international journal of pathology - 1 Jun 2026

Uppin Shantveer G, Hui Monalisa, Thomas Derin Mary, Uppin Megha S, Rao K Nageshwara, Reddy Rajeev, Lingala Himakanth

Abstract excerpt

Though anti-histone H3.3G34W antibody is highly sensitive to giant cell tumours of bone, a subset of tumours which are negative on immunohistochemistry harbours variant H3F3A mutations. In this study, the diagnostic utility of anti-histone H3.3G34V and R immunohistochemistry was assessed along with H3F3A gene mutation analysis by Sanger sequencing. This study also attempted to establish an algorithmic approach to...

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PMID: 41196370
DOI: 10.1007/s00428-025-04319-8

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