Article
Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma.
The American journal of surgical pathology - 1 Nov 2015
Cleven Arjen H G, Höcker Saskia, Briaire-de Bruijn Inge, Szuhai Karoly, Cleton-Jansen Anne-Marie, Bovée Judith V M G
Abstract excerpt
Specific H3F3A driver mutations and IDH2 mutations were recently described in giant cell tumor of bone (GCTB) and H3F3B driver mutations in chondroblastoma; these may be helpful as a diagnostic tool for giant cell-containing tumors of the bone. Using Sanger sequencing, we determined the frequency of H3F3A, H3F3B, IDH1, and IDH2 mutations in GCTBs (n=60), chondroblastomas (n=12), and other giant cell-containing...
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