Article
Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer.
International journal of molecular sciences - 6 Jan 2022
Pálinkás Hajnalka Laura, Pongor Lőrinc, Balajti Máté, Nagy Ádám, Nagy Kinga, Békési Angéla, Bianchini Giampaolo, Vértessy Beáta G, Győrffy Balázs
Abstract excerpt
The clonal composition of a malignant tumor strongly depends on cellular dynamics influenced by the asynchronized loss of DNA repair mechanisms. Here, our aim was to identify founder mutations leading to subsequent boosts in mutation load. The overall mutation burden in 591 colorectal cancer tumors was analyzed, including the mutation status of DNA-repair genes. The number of mutations was first determined across...
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