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Article

A comprehensive analysis of POLE/POLD1 genomic alterations in colorectal cancer.

The oncologist - 6 Sept 2024

Mosalem Osama, Coston Tucker W, Imperial Robin, Mauer Elizabeth, Thompson Christopher, Yilma Binyam, Bekaii-Saab Tanios S, Stoppler Melissa Conrad, Starr Jason S

Abstract excerpt

INTRODUCTION: Pathogenic mutations in POLE/POLD1 lead to decreased fidelity of DNA replication, resulting in a high tumor mutational burden (TMB-H), defined as TMB ≥ 10 mut/Mb, independent of deficient mismatch repair (dMMR) and microsatellite instability high (MSI-H) status. METHODS: De-identified records of patients with colorectal cancer (CRC) profiled with the Tempus xT assay (DNA-seq of 595-648 genes at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38776551
DOI: 10.1093/oncolo/oyae098
PMCID: PMC11379631

Genes

POLD1
POLE
ALK
APC
ATM
BRCA2
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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