Article

Inherited DNA Repair Defects in Colorectal Cancer

2018-01-30

Abstract excerpt

Colorectal cancer (CRC) heritability has been estimated to be around 30%. However, mutations in the known CRC susceptibility genes explain CRC risk in under 10% of the cases. Germline mutations in DNA-repair genes (DRGs) have recently been reported in CRC but their contribution to CRC risk is largely unknown. We evaluated the gene-level germline mutation enrichment of 40 DRGs in 680 unselected CRC individuals comp...

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Literature Corpus work: 3caee054-fb3f-564d-b464-94dfab3e5901
DOI: 10.1101/256917

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