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Article

Recurrent somatic mutations reveal new insights into consequences of mutagenic processes in cancer.

PLoS computational biology - 1 Nov 2019

Stobbe Miranda D, Thun Gian A, Diéguez-Docampo Andrea, Oliva Meritxell, Whalley Justin P, Raineri Emanuele, Gut Ivo G

Abstract excerpt

The sheer size of the human genome makes it improbable that identical somatic mutations at the exact same position are observed in multiple tumours solely by chance. The scarcity of cancer driver mutations also precludes positive selection as the sole explanation. Therefore, recurrent mutations may be highly informative of characteristics of mutational processes. To explore the potential, we use recurrence as a...

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PMID: 31765368
DOI: 10.1371/journal.pcbi.1007496
PMCID: PMC6901237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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